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During the last few months a series of articles were published on this topic in the E-Journal of Cardiology Practice [3-26] in addition to the 2017 Guidelines from the ESC/EACTS [27] and ACC/AHA on the management of valvular heart disease [28], as well as a large number of original papers. 2. ESC Guidelines and Focused Updates undergo extensive review by the CPG Committee and external experts, including members from across the whole of the ESC region and from relevant ESC Subspecialty Communities and National Cardiac Societies. Experience our signature treatments and massages: Escape Remedy Signature Massage, Reboot Aromatherapy Calming Massage, Recover Remedy Stress Points Massage. The 2021 ESC/EACTS Guidelines has been recently published reporting new evidence and making a revision of the previous recommendations necessary. Current ESC guidelines suggest a target LDL-C of 55 mg/dL (1. Take a tour of the 600+ games at ESC Online casino. 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